What happens when a 15-year-old vegetarian learns that a controversial food additive, one that is patented as a flame retardant, is allowed to be added to her sports drink?
Sarah Kavanagh, of Hattiesburg, Miss., started a petition on change.org , asking the manufacturer to remove it. Brominated vegetable oil is allowed by the Food and Drug Administration as an additive “generally regarded as safe.” It has, however, been linked to health problems in some studies, so why put it in a sports drink, her petition argues?
Dog lovers, too, are posting petitions about practices involving food additives that make no sense to them—like testing such ingredients on animals. The requisite safety tests performed on BVO included animals; even dogs.
While rodents are the usual subjects in toxicity tests, dogs are also an important test tool for food additives such as olestra (of gastrointestinal fame); cyclamate (a banned sugar substitute); and countless other compounds, which are administered at high doses in studies.
Supporters of the practice view dogs as “whole, living systems” vital for testing the effects of additives in products sold to humans. Opponents see a cultural disconnect in using dogs to study products to be sold to…well, them.
Surveys show that nearly half of U.S. households have a dog. Another subset have Beagles; the most common laboratory breed. Yet the long-domesticated dog—subject of endless stories of devotion and cultural indulgence in the form of goods and services aimed at their comfort—is, in another context, a disposable species.
Petitioners say that dogs have limited protections in a research setting. Cages restrict their movement, puppies may be weaned early and caged individually, and procedures may hurt, particularly in vivo toxicity tests.
According to the U.S. Department of Agriculture’s website, the Animal Welfare Act of 1966 “is the only Federal law in the United States that regulates the treatment of animals in research, exhibition, transport, and by dealers.”
The Act was prompted by media reports on the theft of pets by dealers who sold them for research. Now most research dogs are “purpose bred,” but they can still be supplied by Class B dealers and legally sourced from shelters, auctions, and ads. As of June 2012, the Humane Society of the U.S. estimates that there were 3,303 USDA Class A breeders and Class B  licensed brokers!
The animal welfare law is enforced “primarily through inspections of every licensed or registered facility in the country.” It regulates cage size, cleanliness, and food and water, but not the tests performed or their duration. The BVO feeding study spanned two years (in dog-years, how long is that, owners may wonder?)
Even when dogs emerge from a study in good health, there is still the “frequently asked question” of what happens when an experiment ends?
According to the website of the American Association for Laboratory Animal Science, “The majority of animals under study must be euthanized in order to obtain tissue for pathological evaluation and for use in in vitro tests.”
The association is a membership group of professionals from academia, government, and private industry that promotes “responsible laboratory animal care and use to benefit people and animals.”
In one petition on whitehouse.gov, the Dogington Post “internet newspaper” offers this appeal to the Obama administration: “Beagles aren’t reliable test subjects.”
In fact, many food additives such as BVO remain controversial long after tests in dogs were used to determine what a safe dose might be in human foods.
Like olestra, a substitute for fat. A 20-month olestra feeding study in dogs states that the objective “was to assess the potential chronic toxicity of olestra in a non-rodent species.” The study found that “olestra was not toxic when fed to dogs at up to 10 percent of the diet for 20 months.”
The dogs, 4-6 month old Beagles divided into groups of 10 for testing, were euthanized when it was over and the study was published in 1991. Yet olestra garners plenty of consumer complaints.
The sweetener Sucralose aka Splenda was also tested in Beagles. Sourcewatch.org  describes one test that involved 32 Beagles caged for 52 weeks at the McNeil Specialty Products laboratories in New Jersey. At the end of the study they were anaesthetized and bled to death, which made the examination of organs easier.
An alternative to BVO in beverages, the Eastman product Sustane SAIB (sucrose acetate isobutyrate)—though not a source of consumer complaints—was tested in Beagles, too.
The list of additives is long, and some say, getting longer. Consumer interest in health keeps the food industry experimenting with flavors, plant extracts, supplements, stabilizers and more. As they strive to churn out the substitutes, animal petitioners hope to see new substitutes for dogs in their toxicity tests.
Also promoting humane alternatives is the Physician's Committee for Responsible Medicine, which is pulling for a robot to the rescue. Like the promising “Tox21,” a collaboration of federal agencies to test chemicals—including food additives—with a machine, at blazing speed. The evolution of technology, they say, will minimize the use of animals.