Wellness: Food & Nutrition
What’s gotten into food safety?
We’re barely halfway into the year and already, there have been a flurry of pet food recalls. The sheer number of brands has been surprising, as have the names of the brands involved; we’ve seen recalls from some of the industry’s most respected companies. How and what we feed our dogs (and ourselves, for that matter) is such a fundamental issue that we’ve decided to do a series of articles on pet food safety, starting with a report on a few of the most recent recalls. We examine the reasons behind them, lessons learned and what we might expect in the future.
Until very recently, all recalls have been voluntary (a confusing term that can lead consumers to believe that a recall is optional), triggered for a variety of reasons: mislabeling, misbranding, the inclusion of potential allergens or adulterants, or contamination with a pathogen such as one of the varieties of salmonella. And some products are recalled simply because they were produced at the same factory during the same timeframe as the affected food.
So far, no pet food recall has been as widespread as the one in 2007, which involved the Menu melamine scandal. If Hurricane Katrina taught policymakers the importance of the human/ pet bond, the ’07 Menu Foods recall did the same for the focus on the safety of the food that we feed our pets. As William Hubbard, a former FDA official, notes, “I do think that this pet food thing has shown people … that something needs to be fixed. If this is not a wake-up call, then people are so asleep, they are catatonic.”
It took a while for Congress to fully awaken, but in 2010, the Food and Drug Administration (FDA) was given more power with the passage and then signing into law by President Obama of the Food Safety Modernization Act (FSMA). The act marks the most sweeping food-safety reform since the Great Depression.
This new act will soon be putting broader issues into the spotlight. For the first time, the FDA will be empowered to more aggressively regulate and enforce preventive measures. Recalls will no longer just be voluntary, but rather, can be mandatory. In our opinion, given this new regulatory power and the plethora of places from which pet food manufacturers source their ingredients, the number of recalls will surely rise. Closer attention and accountability are good for consumers and the animals we feed, and definitely something we need to be informed about.
RECALL CLASS OF 2013
We have the New York State Department of Agriculture and Markets to thank for finding what might be the contributing factor: the department identified antibiotic residues not approved for poultry in the U.S. in the treats. This spurred Del Monte, the makers of Milo’s Kitchen Chicken Jerky Treats, and Nestle Purina, manufacturers of Waggin’ Train and Canyon Creek Ranch dog treats, as well as others, to finally initiate a nationwide removal of these products from store shelves.
Though the FDA continued to claim that “there is no evidence that raises health concerns, and that these results are highly unlikely to be related to the reports of illnesses,” the findings were enough to convince the slow-moving food industry that they needed to get the products out of circulation. The FDA, which still considers this to be an open investigation, notes that they “welcome additional information about New York’s testing methodology …” To date, the treats are thought to have contributed to the deaths of roughly 500 dogs and nine cats. If New York’s state inspectors had not found the illegal antibiotic residue, those treats would still be available. Chalk one up for the state team!
DOMESTIC PRODUCTS TAKE A HIT
In February of this year, Kasel had the dubious distinction of being the first pet food manufacturer to possibly face a first-ever FDA/FSMA mandatory recall notice, a threat based on inspections by an FDA team that found a number of infractions: “All of the finished pet treat product samples and 48 out of 87 environmental samples collected during the inspection tested positive for salmonella. More than 10 different species of salmonella were found in the firm’s products and manufacturing facility, indicating multiple sources of contamination.” The jerky treats were sold through a number of big-box retailers, including Target, Petco, Sam’s Club and Costco.
Other jerky products made in Kasel’s Denver plant were drawn into the recall as well. Bixbi, an up-and-coming independent brand from Boulder, had batches of their products swept up, and Nutri-Vet, a more established brand, was also named, although it was noted that none of these products had tested positive for bacteria. (I contacted the owners of Bixbi and Kasel, who responded to my questions; I also placed numerous calls to Nutri-Vet, who didn’t reply.)
Treats aren’t the only products in which salmonella has been found, however. Natura, a premium holistic brand now owned by Procter & Gamble, had its first recall experience this year after one of their dry-food products tested positive for salmonella by Michigan inspectors. When I spoke in late March to Jason Taylor, a P&G spokesperson, he said the company was still in the process of trying to recreate the production situation at the time the contamination happened; they were, however, sure that it had occurred during a post-extrusion step. “We have an extrusion [cooking] process that is scientifically proven to kill pathogens … So it probably happened either at the dryer or packaging line.” According to Taylor, the company has a complex manufacturing process in place to ensure that their products are contamination- free. Their microbial-mitigation process, which has more than 100 steps, addresses each step the food goes through, from raw material through packaging.
Taylor said that the company was fairly confident that the problem was limited to products manufactured during the two-week period beginning December 17, 2012, and ending January 2, 2013. Since then, we learned that they extended the recall for products manufactured up through March 24, 2013— making this a larger-scale recall.
RAW FOOD PRODUCTS UNDER THE MICROSCOPE
While most of Honest Kitchen’s rawfood sources are in North America, they also get some produce from Europe and exotic fruits from Asia. Surprisingly, they get their parsley from Egypt. Yearround availability of organic and/or human-grade ingredients at a reasonable price is one of the challenges faced by smaller food manufacturers like Honest Kitchen, and is the reason for this wide-ranging sourcing.
Since this incident, Honest Kitchen has switched to another parsley supplier (also in Egypt) and added a new step to their processing of dried herbs and leafy greens, treating them with a gentle steam sterilization to protect against microbial pathogens.
More raw food companies were hit with recalls in March, when the Minnesota State Department of Agriculture found salmonella, first in Steve’s Real Food Turducken patties, and a week later in a two-pound tube of Bravo! Chicken Blend raw frozen food diet the agency had purchased from a local pet store.* I talked with veterinarian Heidi Kassenborg, director of Dairy and Food Inspections for Minnesota, to get a better idea about her state’s pathogen inspection process.
Many have observed that while salmonella is the most prevalent foodborne pathogen, few dogs actually become ill from it, and I asked her why the FDA and her agency have such a strong concern about its presence in pet food. She explained that they are charged with finding adulterants in food, and “in food items, salmonella is considered to be an adulterant.” As for the USDA’s salmonella-tolerance level for raw poultry (now at 7.5 percent, down from 20 percent in 1996), she confirmed that “in raw food, like poultry and beef, it is not considered to be an adulterant.” Basically, there is no tolerance for adulterants in finished food items, and even raw diet is considered a “food item.”
Kassenborg explained the high concern about pet food, saying that since pet food is handled by humans, they are exposed to any pathogens that may be in it; these pathogens can also be excreted in the pet’s stool. Given that salmonella can cause serious and sometimes fatal infections in young children, the frail or elderly, and those with weakened immune systems, this is indeed a compelling reason for concern.
She went on to say that there would be increased surveillance now that raw diet has tested positive for pathogens. “Once things are found in one food type, they start looking at it and testing more. We have an obligation to find out if it is a widespread problem. And if so, is there a way to produce it better without it becoming contaminated?”
Doug Lueders, supervisor of Minnesota’s Commercial Feed Regulatory Program and the person responsible for its product-sampling plan, concurs. “If we have a category that has had few [contaminants] or none, we may switch our emphasis to one where we have had a problem. I think we will raise the percentage [of resources] that we have devoted to raw in the past; that, however, will be at the expense of something else.”
Resource allocation is a real issue. Other states have registered positive hits on items like jerky and kibble, so even though there might not be direct interstate coordination of efforts, Lueders says, since “Michigan found salmonella in one brand of pet food, it probably doesn’t serve much practical purpose for us to look at the same brand ourselves. There is an old adage that says an absence of evidence is not evidence of absence, so we wouldn’t continue to test the same pet food for salmonella in hopes of finding more salmonella, or hoping to find that it is clean …”
THE PRICE OF SAFETY
Prior to processing a food in their facilities, suppliers must certify that the food is pathogen-free. Throughout the manufacturing process, pathogens are tested for and eradicated. A few NARPA members use what is known as highpressure processing or high-pressure pasteurization (HPP), which disrupts a pathogen’s cell walls. Miller says that this very expensive system is considered by the general food industry to be stateof- the-art in controlling pathogens.
Companies like Bravo! also batchtest and follow a test-and-hold system, meaning that finished products are not shipped from their plants until negative pathogen reports are in hand. A Bravo! spokesperson described the company’s process: “Most established companies in raw diet own their own facilities. We [at Bravo] come out of the meat business and our facility is a USDA facility for human food, so we have standards we have to keep up. We have a USDA inspector who checks the plant daily to make sure that [things are] being done by the books [and] we have a HACCP [Hazard Analysis Critical Control Points] plan in place. What consumers should be looking for are companies who use ‘test and release’ and batch testing, and have HACCP plans.” He also noted that the company’s website will soon have a function that will allow consumers to enter an item number and “best used by” date and receive test results for E. coli, Listeria and salmonella.
This type of high-level testing increases the cost of the final product; as Miller observes, “you can’t add a whole level of pathogen controls and not have a resulting increase in cost to consumers.”
THE BOTTOM LINE
But while smaller brands can be devastated by such events, companies who have worked hard and long to develop a loyal customer base can, most likely, recover from them, as can internationally distributed brands such as Natura.
I don’t believe that most of these pet food companies and manufacturers acted recklessly. But after a recall, it shouldn’t be business as usual. Measures need to be taken to identify where the contamination came into the system, and pathogen controls need to be improved. Changes need to be made—for some businesses, that may mean switching manufacturers, raw-material suppliers, warehouses or distributors, or even instructing pet stores on proper handling and storage techniques for their products.
It’s also critically important that they pay attention to how customers are notified (and receive compensation or refunds). For example, I commend Honest Kitchen for quickly alerting its customers via email, social media and website notices. Retaining the trust of customers requires companies to be transparent, forthcoming and ready to make production and sourcing modifications, as they and a few other companies have done.
Realistically speaking, it’s unlikely that the food system can be made 100 percent safe. Nonetheless, we need to know we can trust that those who make the food we feed our companion animals are held to the same standards as those who supply the food we eat ourselves.
Over the years, we’ve become well aware of the concept of food sourcing. In addition to knowing exactly what goes into the food we feed our dogs and cats, we also need to know where it comes from. How the finished products are processed, packaged and distributed is also vitally important. As P&G’s Taylor observed, pathogen elimination is challenging when working with large quantities of raw meat and poultry.
Do some food processors take shortcuts to save money? For some, that might be the case, as evidenced by the huge 2012 recall involving a Diamond co-processing plant in Gaston, S.C. , which ultimately affected 17 brands representing more than 30,000 tons of dry dog and cat food. Because a rare strain of Salmonella infantis was found in some product samples, all brands, ranging from high-end Wellness to Costco’s brand, Kirkland, were recalled. According to the Centers for Disease Control and Prevention, at least 49 people in 20 states and two in Canada who came in contact with pet food made at this facility are confirmed to have been affected. When the FDA inspected the plant, they found numerous problems with the contamination-containment processes, including the use of cardboard and duct tape on some of the equipment. How they got away with this—how they managed to fly under the radar of the companies for which they were making food—is anyone’s guess.
Yet another problem that cries out for better monitoring involves actually getting recalled products off store shelves. A reporter for a Colorado television station found bags of the tainted Chinese jerky in stores such as Safeway, K-Mart and Albertsons almost a month after it had been recalled. I learned about this from attorney Jennifer Reba Edwards of the Animal Law Center in Wheat Ridge, Colo. As Edwards points out, “The bigger problem is [that] once recalled, the products are still getting to the end user. Retailers are not pulling the products from the shelf and you can buy them online; that is almost a bigger problem than the recall itself—preventing it [from] being available to the end user.” Who is responsible for this step? Who should be held accountable? This is definitely a problem to track and one that consumers need to be aware of.
Within the dog community, the issue of salmonella is controversial; some question its potential to harm dogs. However, I don’t believe this is debatable. There are too many instances in which people have been damaged by cross-contamination or mishandling in the home of food intended for pets. The FDA considers it to be an adulterant in both human and animal foods, as well they should. More to the point, as Jennifer Edwards says, “I’m pregnant; I would really be upset if I were to be exposed to salmonella. It goes beyond protecting our animals—we have to protect our people as well.”
If ever there was a reason to look at the big picture, this is it. We have only one food supply, and it should be safe for both humans and animals. This is, and ought to be, the standard that foodsafety regulators, the food industry and we—the consumers—need to meet.
*A Bravo! company spokesperson told me that the product that tested positive had been tested by a third-party inspector before leaving the plant and had a negative-contamination finding. In an unusual step, the FDA allowed that point to be included in their recall statement.
Wellness: Health Care
DEA action might hinder in-home vet practices
Legislative Alert: We need your help! Please Support S. 950, the Veterinary Medicine Mobility Act, to Allow Veterinarians to Continue to Transport Vital Medications for the Treatment of Animals!
The American Veterinary Medical Association (AVMA) is seeking urgent modification to the current Controlled Substances Act (CSA) that was put forth by the Drug Enforcement Administration (DEA) in 1970. The CSA was designed to protect public health by preventing diversion and improper use of controlled substances, and was actually implemented with the human medical field in mind. Well, the DEA is now suddenly interpreting the wording in this 43-year old legislation and has recently deemed it illegal for veterinarians to transport controlled substances outside of the veterinarian's single registered location, typically their hospital or clinic.
What does this mean? It means that it is now illegal for veterinarians to carry and use vital medications for pain management, anesthesia and euthanasia in house calls, in veterinary mobile clinics, on farms, or in ambulatory response situations such as injured wildlife. It now prohibits mobile veterinarians, rural or farm veterinarians, and in-home euthanasia veterinarians from doing their job because of this sudden and literal interpretation of the law. As a provider of hospice care for pets, this hits especially close to home for me: I am no longer legally able to provide adequate pain relief for my terminal patients, nor am I legally allowed to provide the the gift of a peaceful passing in the comfort of a pet's home. The DEA has already notified veterinarians in some states (California being highly targeted) that they are in violation of this law and are being threatened with fines as well as provoking licensing.
The DEA has officially informed organized veterinary medicine that transporting these controlled substances is illegal per the CSA and thus would require a statutory change in the law to allow “us” to legally provide complete veterinary care to our patients.
We have met this need by introducing the Veterinary Medicine Mobility Act (S. 950), which was introduced by U.S. Senators Jerry Morgan and Angus King just this week (thank you!). This legislation would amend the current CSA and will allow us to continue to treat and meet the needs of our patients—your pets.
Can you help? It is imperative that veterinarians be able to legally transport controlled substances to the location of our patients, and we need your support. By clicking this link you can tell your U.S Senators that veterinarians must be able to properly care for their patients. It takes just seconds- look for the green-colored “TAKE ACTION NOW” at the bottom and with just 1 click, you can make a world of difference for our pet family members.
Wellness: Healthy Living
Tips on keeping your dogs safe
It’s the season, in California and in other states, when foxtails are starting to rear their “ugly” and dangerous seed-heads. These days after our morning walk, and before I load the dogs into the car, I do a complete check-up on them. I need to comb Lola, because she has a shaggy, wired coat, and her high-leaping, coursing style of recreation, attracts burrs, seeds, and unfortunately the worst of them all, foxtails. Checking each toe, paw pads, nose, ears, eyes—I also pat around the other two short hair dogs, attention that they really enjoy. Here are two wellness articles from our two vet bloggers, Shea Cox and Nancy Kay, that will tell you everything you might need to know about keeping your dog safe from these flora pests. There was also a good article in Gun Dog magazine back in 2010. What that piece shows is that foxtails are spreading to other areas of the country.
P.S. A couple days after posting this blog, Charlie, my little Terrier, got one up his nose. Poor guy, he sneezed like mad, and then stopped. Some people believe that the stopping means a dog has expelled the foxtail through sneezing, but unfortunately that is not usually the case. Only means that the darn thing has moved further up the nasal passage. It is always wise to have a vet check it out.
The American Heart Association issued a scientific statement yesterday that yes, owning a dog may protect us from heart disease. The statement was issued by an expert panel that was convened to look at alternative approaches to combat heart disease. They were prompted to look at the benefits of pet caring because of the growing number of medical studies linking pet ownership to better health.
Dr. Levine, a professor at the Baylor College of Medicine said, “there are plausible psychological, sociological and physiological reasons to believe that pet ownership might actually have a causal role in decreasing cardiovascular risk.” Dog ownership, partially because it compels people to walk their dogs and thereby getting more exercise, proved more beneficial than owning a cat. Richard Krasuski, a cardiologist at the Cleveland Clinic, thought this statement as more of an indictment of societal attitudes toward exercise. “Very few people are meeting their exercise goals,” he said. “In an ideal society, where people are actually listening to physician recommendations, you wouldn’t need pets to drag people outside.” (Feeling that walking my dogs is one of the greatest daily pleasures in my life, I would not quite agree that many of us actually consider our dogs as “dragging” us outside.)
“Several studies showed that dogs decreased the body’s reaction to stress, with a decrease in heart rate, blood pressure and adrenaline-like hormone release when a pet is present as opposed to when a pet is not present,” Dr. Levine said. Pet owners also tended to report greater amounts of physical activity, and modestly lower cholesterol and triglyceride levels. Some research showed that people who had pets of any kind were also more likely to survive heart attacks. All in all a definite win-win for us and our dogs.
The research also strongly suggested that there was a sharp contrast between those who walked their dogs themselves and those who did not.
Dr. Levine concludes by saying that they were not recommending that people adopt pets for any reason other than to give them a good home.
“If someone adopts a pet, but still sits on the couch and smokes and eats whatever they want and doesn’t control their blood pressure,” he said, “that’s not a prudent strategy to decrease their cardiovascular risk.”
Wellness: Healthy Living
Choose toys with more than fun in mind
They make the world go round. They make it bounce, roll and soar. They’re objects that inspire play, enrich training, ease boredom and curb problem behaviors. Toys, according to the experts (and every dog worth his molars), are a must-have.
Despite the constant media comments about how we pamper our pets, toys are no mere luxury. Experts say that dogs need them, and need more than one kind. That doesn’t mean more bells and whistles, just different types. Toys can take the edge off a bad day, like a stress ball you squeeze when you’re mad. Softer toys a dog can “baby” satisfy gentler instincts. Frisbees, balls and tugs are ways to share the fun, while squeaky playthings cry out for attack.
The question is, which toys? With a global pet economy, the options—and problems—keep growing. On the pet aisles, shoppers are greeted with all the persuasive power of an infomercial. Bright, funky objects, packaged to the nines, demand closer inspection—but not too close. The readable text is mostly advertising, not information. “The packaging for these products is incredible and totally deceiving,” says Pattie Boden, owner of the Animal Connection in Charlottesville, Va. Boden, who is picky about sourcing safe, natural toys to stock her shelves, says that a 25-year career in advertising has made her a skeptic.
Unfortunately for dogs and owners, manufacturing of pet toys relies on the honor system; for less scrupulous companies, it’s trial by error. In some cases, even errors (discovered through consumer complaints) are ignored. Choose carelessly and our dogs may pay the hidden cost. Among the most familiar hazards are choking and stomach obstruction. Pieces as well as particles may be ingested, and since our pups use their mouths to play, toxic materials and coatings also pose a risk. Yet the Food and Drug Administration doesn’t regulate dog toys, and the Consumer Product Safety Commission only regulates pet toys that can be proven to put consumers (people, not dogs) at risk.
This reality hits hard when a beloved animal is injured at play. One such horror story became news after a dog’s tongue was trapped in a hole in a ball, requiring long and painful medical intervention and finally, amputation of the tongue. The owner was shocked to learn that this wasn’t the first such incident—other dogs had been harmed, even killed, by the same toy. The company, Four Paws, eventually recalled several of its toys, according to its website.
Denise Smalt, a trainer in upstate New York, issues a warning about the harmless- seeming tennis ball. Eight years ago, Smalt sold a Shepherd puppy to a couple. “Even though I tell all my puppy people, as well as all my obedience students, how dangerous tennis balls are for large breeds, they still let their Shepherd play with tennis balls because they had always let their dogs play with them, and had no problems. At two years old, the dog choked to death on a tennis ball in front of his owner. I use his story to help save others,” she says.
The concerns don’t end with injuries and choking hazards. While dyes, preservatives and chemical residue are nothing new, a string of toxic Chinese imports has sparked fresh worries. Tests conducted by ConsumerAffairs.com found a variety of mainstream toys tainted with toxic heavy metals, including cadmium, lead and chromium. From cancer agents to neurological poisons, these chemicals are released from affected toys when dogs lick and chew them, according to Dr. Ernest Lykissa, the toxicologist who assessed them. Another lead-laden plaything is made from latex—a material sometimes recommended in lieu of plastic, which may contain phthalates and BPA (hormone disruptors). Adding to the problem of contaminants is a dearth of toxicity data for dogs. What’s presumed safe for a 40-pound child may be deadly for a half-pint Chihuahua.
“Please don’t think because things are made in the U.S. that they are safe,” Ann Martin, author of Foods Pets Die For, an exposé of the pet food industry, advises. “The massive pet food recall is a good example. They did not bother testing any of the raw materials going into these foods; hence, numerous dogs and cats became ill or died.”
Still, the perception is that U.S.–made means safer. At an H.H. Backer pet trade show in Baltimore, Pattie Boden looked hard for new toys made in the U.S. She found just one. Ironically, the only certified organic toy she could find was made in China. But a few U.S. companies are indeed producing quality toys, and the shorter the production path, the better. Some companies use recycled materials (though that’s not synonymous with safer toys, it’s better for the planet). And a company focused on “earth-friendly” products is more likely to avoid problems with toxic materials.
What makes a toy special to a dog may escape human logic, but knowing your dog can help you make wiser choices.
Do you have a Type-A chomper? Technically, dogs don’t chew toys, but rather, tear and shear them as they would prey, using their premolars and molars. These teeth are situated farther back in the mouth, and any toy that finds its way into this set of grinders is a potential victim—so look for appropriately sized toys your dog can’t work to the back of his jaws. Martin relies on her dog Kodi’s play style to choose his toys. The 160-pound Newfoundland is a power chewer who “eats rather than plays with toys. He has some very good squeaky toys he has not destroyed,” she says. Most of his playthings “are the heavy-duty rubber kind.” Kodi’s style, not his large size determines Martin’s toy selection; a small dog can be a power chewer just as a giant breed can be gentle on toys.
From hyper puppyhood to senior moments, knowing your dog also means selecting toys based on his life stage. A dog who’s teething doesn’t play like an old soul whose teeth are worn. A rambunctious adolescent craves different toys than a placid adult dog.
Before buying, use your senses. Strong chemical smells indicate residual chemicals. Brightly dyed fabrics may contain toxic ingredients and leach dye when wet. (Fabric dyes aren’t tested for consumption.) Avoid toys treated with fire retardants or stain guard, as they may contain formaldehyde and other chemicals. Study labels and visit manufacturers’ websites for additional information. Conscientious companies are transparent about their processes.
Safe fun: two words that often collide in a dog’s world, where mysterious edges and flimsy seams can make the most alluring objects. As long as the toy industry is an unsupervised playground, it’s up to loving owners to keep their eyes on the ball …and ring and squeaker.
Nina Ottosson Zoo Active
West Paw Design
Wellness: Healthy Living
When it comes to remedying diseases and disorders, dogs and people are in it together
Call it a movement, a philosophy, a revelation or a revolution.
Call it “one medicine,” “one health” or “zoobiquity.”
Call it something new, or—given that the “aha” moment on which the concept is based came in the 19th century—call it something old that’s been remembered and repackaged amidst the growing awareness that solving the mysteries of animal diseases and disorders, from injured spinal cords to cancer, can lead to possibly curing our own.
Over at least the past five years, there has been a rekindled recognition of the species-spanning nature of diseases, and of the value of species-spanning research. About 75 percent of recently emerging infectious diseases that affect humans have their origins in animals, according to the Centers for Disease Control.
On a theoretical level, the concept of “zoobiquity,” a term coined in the 2012 book of the same name, suggests that, no matter our species, we’re all in this together, subject to most of the same infirmities, capable of passing a lot of them back and forth, and more likely to find cures and treatments if we look at the big picture—at the earth and all its creatures —as opposed to focusing solely on humans.
On a practical level, species-spanning thinking—referred to by various monikers—has led in recent years to veterinary schools reinventing themselves; to a heightened spirit of cooperation between doctors and veterinarians; to new sources of funding for research; and to the realization that, when it comes to diseases shared by humans and animals, the latter may provide a quicker and less expensive route to a cure for all.
Where do dogs fit in? Right at the top. No other animal—if not physiologically, at least in terms of sharing our genetic markers and our home environment—is as close to us.
That’s why Texas A&M veterinarians and University of California, San Francisco, medical researchers have teamed up to study spinal problems in Dachshunds and other dwarf breeds and to test a new drug that blocks secondary infections. The research, which is funded by the Department of Defense, has potential application to battlefield injuries
That’s why, in New York, veterinarians with the Animal Medical Center have joined forces with physicians and researchers at the Memorial Sloan-Kettering Cancer Center to set up trials in which electrical impulses are used to treat tumors of the urinary tract in canines, with an eye toward possible human application.
That’s why the Mayo Clinic has partnered with two veterinary schools, a medical school and a private corporation to study the effectiveness of a device aimed at predicting and controlling epileptic seizures in both dogs and humans. While traditionally, research into canine epilepsy has been funded primarily by the American Kennel Club’s Canine Health Foundation and breed clubs, the Mayo Clinic collaboration received a $7.5 million grant from the National Institutes of Health.
That’s why Tobi, a paralyzed Golden Retriever, is getting stem-cell treatments that may help him walk again as part of a clinical trial headed by Dr. Natasha Olby, veterinarian and neurologist at North Carolina State University’s (NCSU) College of Veterinary Medicine. The trial will involve as many as 30 dogs over three years.
And that’s why Peggy, a Chihuahua from Albuquerque who was born with three legs, is being outfitted with a “bionic” paw at NCSU. Implanting the prosthetic device, which will have electrodes that connect to her nerves, will allow her to run and scratch, and could add to the growing use of comparable technology in humans.
Similarities between dogs and humans, especially when it comes to genes, are also the basis for Dr. Matthew Breen’s research into the most common cancer in dogs, non-Hodgkin’s lymphoma, at NCSU’s College of Veterinary Medicine. Breen and fellow researchers have, with help from the canine genome map, developed a test that can accurately predict how long a dog treated with chemotherapy will remain in remission. In collaboration with the Mayo Clinic and others, they’re in the process of converting the canine test to a human one.
“If that happens, it will be big news,” says Breen, a geneticist and professor of genomics. Breen lost his first dog to cancer when he was 12 and, as an adult, played a role in the mapping of the canine genome—a game-changing achievement that helped place dogs front and center when it comes to health research.
“It’s likely that we will learn more about cancer by looking at what happens in our dogs over the next five to 10 years than we will in the next 20 to 30 of looking solely at cancer in people,” he predicts.
But the key, he emphasizes, is looking at both at the same time.
“If we consider dogs as dogs, we’ll be able to do so much. If we consider people as people, we’ll do so much. But if we consider them both as mammals, and look at what’s common between them, we will find some intriguing answers.”
The possibilities extend well beyond non-Hodgkin’s lymphoma, and well beyond cancer. Dogs, long our antidote for loneliness, may hold the most promise of all animals when it comes to solving medical mysteries and curing what ails us.
“The answer to some of nature’s puzzles about genetics and disease,” Breen says, “has been walking right beside us for the last few hundred years.”
In reality, we’ve been turning to dogs for thousands of years, sometimes quite cruelly, to try to solve our human ills: from the time of Aristotle, who conducted experiments on live animals, and the era of Galen, whose second-century experiments earned him the title “the father of vivisection,” to the period of Pavlov, whose 19th-century experiments included severing the esophagi of living dogs to better study their digestion and, as a sideline, bottling and selling their gastric juices to the public as a cure for dyspepsia.
Many of the medical treatments we now take for granted were either discovered through the use of dogs or tried on dogs first.
In England during the 1600s, the first administration of medication intravenously was accomplished in a dog, via tubes and a pouch made of an animal bladder. In the 1920s, experiments on dogs led to Frederick Banting’s discovery of insulin. Banting and fellow researcher Charles Best surgically stopped the flow of nourishment to a dog’s pancreas and, after it degenerated, removed it, sliced it up, froze the pieces then ground them up. They named the extract “isletin.” When it was injected into another dog in which they’d induced diabetes, the dog’s blood glucose level dropped.
In the 1960s—long before they were ever slipped into clogged human arteries—stents were inserted into those of dogs. When a ballooning version was developed in the 1980s, it too was first tested on dogs.
Currently, as humans wait to take full advantage of its purported promise, stem-cell therapy is becoming more common—though expensive, at around $2,500 per treatment—in treating dogs with arthritis, hip dysplasia and spinal-cord injuries. Removing, treating and reinjecting stem cells (and even differentiated cells) have led to some miraculous recoveries.
Dogs may have access to novel cures and treatments yet to be made widely available to humans, but there’s a trade-off. They are still, in a way, being used as guinea pigs. The difference is—compared to Pavlov’s day, compared to some of the unsavory experimentation on dogs that still goes on—they’re not healthy dogs, or dogs in whom diseases have been induced. Most often, they’re patients, sick dogs who have run out of alternatives and whose owners have enrolled them in clinical trials in hopes of, if not curing their own pet, furthering research that might help other dogs.
The canine cancer samples from around the country that end up in Breen’s lab come from willing donors, or at least willing owners, many of whom see contributing to such research as a way their dogs can leave a lasting mark.
“By providing that data point, it’s almost a legacy for their own dog,” Breen says. “Every dog we recruit, we ask the owner for a picture to put on our wall of honor. We have hundreds and hundreds of pictures of dogs. It helps ground people in the lab, and makes them realize what they’re dealing with is not just a piece of tissue but somebody’s beloved companion that needs to be treated with the same kind of respect.”
Under microscopes, Breen studies chromosomal changes within cancer cells, changes that have been shown to duplicate those that occur in humans. “If we look at what overlaps, it’s those shared genes that highlight the major drivers in the cancer process,” he says.
The aberration of particular chromosomes allows Breen to identify which therapies will offer maximum survival chances. In lymphoma cases, up to 90 percent of dogs respond to chemotherapy and go into remission, but only about half live longer than nine months. By looking at the genetic differences between the dogs who survive for short times and those who survive longer, Breen’s team has developed a test that determines how long a dog will stay in remission; this test will, it is hoped, eventually be available for use with humans.
Experts estimate that one in four dogs will develop cancer in their lifetime. About 50 percent of those over age 10 will die from it. The types, incidence and outcomes aren’t always identical to those in humans, but even in those differences, other clues and opportunities may be found.
Bone cancer, or osteosarcoma, for example, affects a whopping 60,000 dogs a year. In humans, there are only about 900 cases a year and, as a result, its research has never received the kind of funding awarded to work being done on more widespread cancers.
By looking at the disease itself, as opposed to its effect on a singular species, some less high-profile diseases (in humans) can get more attention, and progress can be made more quickly, Breen says.
“We ignore whether it’s in dogs or people, focus on the cancer and get to the biology faster.”
Down the road, such research might keep someone else from hearing those five fateful words Breen remembers hearing as a child, when his own Border Collie cross was stricken with cancer: “There’s nothing we can do.”
Rudolph Virchow, though he wasn’t credited for it in his lifetime, is considered the father of “one medicine.” The 19th-century pathologist coined the term “zoonosis” and created the field of comparative pathology.
“Between animal and human medicine there is no dividing line—nor should there be,” he said. “The object is different but the experience obtained constitutes the basis of all medicine.”
Two centuries later, a variety of factors breathed new life into his old idea. Recently identified zoonotic diseases, like swine and avian flus and West Nile virus, became major public health concerns. At the same time, dissatisfaction was mounting with research studies involving mice, primarily because their findings often weren’t transferable to humans. There was a growing recognition that all animals, both wild and domestic, serve—like the canaries once used in British mines—as sentries for environmental hazards.
Dogs, while at the forefront of much modern research, also played a large role in reviving the species-spanning way of thinking. On top of the tremendous diagnostic and research value it held for dogs, the successful completion of the canine genome map in 2005 showed how similar dog genes are to our own. It also reinforced how much more quickly canine health research can progress. Mapping the sequence of the canine genome cost about $50 million and took one year, while mapping the humane genome cost more than $3 billion over 15 years.
It was one year after that benchmark, in 2006, that the American Medical Association and the American Veterinary Medical Association issued a joint declaration encouraging more partnerships and information sharing between the two branches of medicine.
For far too long, doctors of human medicine and doctors of veterinary medicine—and researchers in the two fields—operated on separate planes. By coming together and sharing their findings, proponents of one medicine held, new opportunities could be realized and new cures, possibly, found.
To those involved with treating and researching animal diseases, the increased respect from those in the world of human medical research is palpable. Dr. Jorge A. Piedrahita, geneticist and professor in the Department of Molecular Biomedical Sciences at NCSU’s College of Veterinary Medicine, remembers a time when overtures from the veterinary medical community to the human one would result in “blank stares, as if they were thinking, What would we want with you?”
“The human medicine field in the past has looked at us [veterinary schools] as technicians,” he says. “They came to us if they needed a pig or a dog, but they never saw us as partners. Now we sit with them really as equals.”
Piedrahita serves as director of the Center for Comparative Medicine and Translational Research, which was created seven years ago. Based at NCSU, one of the first vet schools in the country to fully jump on the one-medicine bandwagon, the center includes 116 researchers at five colleges. The thinking behind the center, he says, is “if we help one species, we’re helping all of them.”
Since then, Piedrahita says, the road between veterinary practitioners and doctors has become much more of a two-way street. “There have been an amazing number of new interactions, and we’re still a very young center. It’s really becoming almost like a partnership.”
Doctors and vets are not the only two cultures the movement has brought closer together, he notes. It has also led to “increased sharing between clinicians, or those working with patients, and researchers, who are confined to labs.” The result, he says, is faster and more efficient research, capable of reaching solutions sooner.
Breen’s cancer research is one example of that. Another is a project Piedrahita is involved with in conjunction with Wake Forest University’s Center for Regenerative Medicine, which is seeking a solution to urinary incontinence.
While it’s a significant issue for women, especially elderly ones, one might not think that dogs—generally a less-prone-to-embarrassment species—would rank it too high, even the spayed ones, in which it is most common. Piedrahita is quick to correct that thinking.
“It’s a very big deal,” he says. “It’s the reason many of them end up in shelters, or being returned to shelters. For the dog, it may not be that big of a deal, but for the owner, it is.”
Throw in its human applications, and it becomes even bigger.
Using cells from the patient—for now, canine patients—the treatment involves reinjecting cells, usually taken from a leg muscle, into the urethral sphincter itself, where they regenerate and build new muscle. The project has received funding from the American Kennel Club’s Canine Health Foundation, and clinical trials involving as many as 40 dogs were expected to begin in January.
Of all the microscopic matters detected in a typical veterinary research lab, irony is not usually among them. But here’s one that has surfaced.
Among purebreds, breeding for certain traits, and to get a certain look—most often accomplished by using dogs who are closely related—has led to recessive disorders, more than those found in any other animal except humans.
It’s believed to be why Boxers are prone to mast-cell cancer and brain tumors, Scottish Terriers to bladder cancer, and Bernese Mountain Dogs to histiocytic sarcoma. It’s why one in five Golden Retrievers is diagnosed with hemangiosarcoma.
But the limited genetic diversity that has led to cancer-causing mutations in many purebreds is also what has led to dogs becoming such a valuable tool in studying disease. Breen compares it to tuning in a radio station. With the dog genome, there’s none of the noise and static from competing frequencies—just a clear signal.
Pointing fingers is useless, Breen says. “I don’t blame anybody.” But he’s among the first to admit that limiting the gene pool has made purebred dogs “a very powerful tool for simplifying genetics.”
With their “less noisy” genetic make-up, purebred dogs offer a speedier research route. It takes thousands of human patients with cancer to identify risk factors, he notes, but the same can be accomplished with as few as 100 canine patients.
In the book Zoobiquity: What Animals Can Teach Us about Health and the Science of Healing, Barbara Natterson-Horowitz, a cardiologist who consults with the Los Angeles Zoo, delves into the many sicknesses we share with animals. (Editor’s note: For a review of Zoobiquity, see the October 2012 issue of Bark.)
Co-authored by Kathryn Bowers, the book points out that not only humans get breast cancer, but kangaroos, beluga whales, wallabies and sea lions—to name a few—do as well. Rhinos get skin cancer; gorillas get depressed; horses suffer from erectile dysfunction; and sexually transmitted diseases plague the non-human world as well, from syphilis in rabbits to chlamydia in koalas.
By looking at the big picture, we’re likely to further our understanding of species-spanning diseases, of the planet and of the environmental factors that contribute to ill health. Two annual conferences on zoobiquity have urged medical practitioners to do just that.
In terms of the latter, dogs, once again, serve as prime examples and perfect models. They sleep in our beds, share our food, lie on our flame-retardant-treated couches and frolic on our insecticide-treated lawns. When we go for a walk, it’s usually with them at our sides or pulling us along behind them.
They may soon lead the way in science as well, as rodents take a back seat when it comes to research examining the role environmental factors, such as secondhand smoke and household chemicals, play in causing disease. While much of it was going on years before the AMA-AVMA declaration was announced or the term “zoobiquity” was coined, research involving dogs (and cats) is increasingly looking at the link between pollutants and cancer.
On top of the fact that the canine genome is 80 to 90 percent similar to that of the human, dogs are constantly at our sides, making them perfect candidates for studying not just cures but also, causes.
Since dogs are such accessible and efficient, not to mention friendly, models, the question arises (or at least ought to): should one health/one medicine/zoobiquity—and more particularly, the view of dogs and other animals as sources of solution to our own diseases—raise animal welfare concerns?
Despite their all-inclusive, holistic and harmonious sounding names, none of the calls for a species-spanning approach to medicine state that all animals are our equals, or that their value parallels that of humans. Only that they get many of the same diseases we do.
As cures come closer and as dogs are increasingly seen as the road to such cures, could our zeal lead to what animal-welfare advocates might see as reckless driving?
The book Zoobiquity points out that in virtually all of the examples it uses, animals involved in the research were already sick. When, on ABC’s “Nightline,” Natterson-Horowitz was asked if the concept could lead to testing on healthy animals—if the Hippocratic Oath of “do no harm” should apply, for instance, to hippos—she replied, “I can’t give you a simple answer, because it’s a very complicated, nuanced question.”
Breen, for his part, doesn’t hesitate. “We don’t induce cancers in dogs. The key issue about cancers, and many genetic diseases in our dogs, is that these are all spontaneous conditions … All the dogs in our study are part of a family, sharing their homes and their lives. The path to discovery involving cancer and our dogs is one we walk along side-by-side with the owners.
“We have access to state-of-the-art technologies to ask key questions, but these are worthless without the willingness of the dog-owning community to collaborate by submitting cancer specimens from their dogs. By building a strong relationship with pet owners, and realizing that their pets are like family members, like a child … it actually means the chances of ever inducing disease are less. I just can’t see it happening; it wouldn’t happen in my lab, let’s put it that way.”
Breen’s bigger fear, when comes to biomedical research, “is that all this will raise people’s hopes too high and too soon.”
That applies to the owners of afflicted pets as well as those who are afflicted themselves, or have human loved ones suffering from a disease. We’re eager to find cures. Dogs, being such perfect models for study, provide what may be one of the quickest routes to them. While a resurgence in the use of otherwise healthy dogs in intrusive experiments isn’t likely, the future (which seems to be getting here faster and faster) isn’t crystal clear.
This much is, however: fairly early in their domestication—and in what was perhaps one key component leading to it—dogs exhibited their ability to stand sentry, to serve humans by warding off dangerous, life-threatening intruders.
In a way, thousands of years later, they’re doing it again.
News: Guest Posts
Overcoming fear, Learning to trust again
Many dogs, rescued from the trauma and abuse of puppy mills or hoarders, need lots of extra TLC before they're ready for their forever homes.
Lacking social skills, having lived with fear, pain, and hunger, some remain overwhelmingly fearful even after being removed from their deplorable conditions and given physical, medical and emotional support. Their psychic wounds can cause them to cower, retreat from a loving touch, pee submissively, even growl or bite to keep humans and other animals away.
Such behaviors, while understandable, make them a challenge for shelters already overwhelmed with dogs needing homes. Fearful dogs often become part of a revolving door problem, being returned to shelters by adopting families ill-equipped to deal with the behaviors. Or worse, they may be euthanized because they can't be placed.
ASPCA (American Society for the Prevention of Cruelty to Animals) has created a flagship program that will attempt to fill the gap between rescue and placement for the most severely traumatized dogs, the fearful ones. The ASPCA Behavioral Rehabilitation Center at St. Hubert's Animal Welfare Center in Madison, N.J. opens this week.
"For some animals, the reality is that after a lifetime of neglect and abuse, the rescue is just the beginning of their journey to recovery," said Dr. Pamela Reid, vice president of the ASPCA's Anti-Cruelty Behavior Team. "The ASPCA recognized the need for a rehabilitation center that will provide rescued dogs customized behavior treatment and more time to recover, increasing the likelihood that they will be adopted. We partnered with St. Hubert's Animal Welfare Center and identified the unique opportunity to utilize their space and collaborate with their behavior and care experts for the rehabilitation of victims of cruelty and neglect."
To start, dogs rescued from animal cruelty investigations will be eligible. To help reduce these dogs' fears and anxieties, the rehabilitation team will gently introduce them to unfamiliar sounds, objects, living spaces and real-life situations that a normally socialized dog handles with aplomb, but can induce trauma and extreme stress in this special population of dogs.
The ASPCA has funded this project for two years. The work done at the Center will become part of a research project, studying and evaluating methods for rehabilitating undersocialized, fearful dogs. The findings will be shared with animal welfare organizations and other researchers nationwide with the goal of helping shelters and rescue organizations rehabilitate abused and fearful dogs coming into their own facilities.
Recalled Because of Posssible Health Risk
Steve’s Real Food Recalls Turducken Canine Recipe Patties Because of Posssible Health Risk
March 7, 2013 - Steve’s Real Food of Murray, Utah is recalling its 5 lb. bags of Turducken Canine Diet – 8oz. Patties due to potential contamination of Salmonella. Salmonella can affect animals eating the products and there is risk to humans from handling contaminated pet products, especially if they have not thoroughly washed their hands after having contact with the products or any surfaces exposed to these products.
Healthy people infected with Salmonella should monitor themselves for some or all of the following symptoms: nausea, vomiting, diarrhea or bloody diarrhea, abdominal cramping and fever. Rarely, Salmonella can result in more serious ailments, including arterial infections, endocarditis, arthritis, muscle pain, eye irritation, and urinary tract symptoms. Consumers exhibiting these signs after having contact with this product should contact their healthcare providers.
Pets with Salmonella infections may be lethargic and have diarrhea or bloody diarrhea, fever, and vomiting. Some pets will have only decreased appetite, fever and abdominal pain. Infected but otherwise healthy pets can be carriers and infect other animals or humans. If your pet has consumed the recalled product and have these symptoms, please contact your veterinarian.
The recalled Turducken Canine Diet – 8oz Patties in a 5 lb. bag were distributed from October 2012 to January 2013 in retail stores in Connecticut, Massachusetts, Maine, New Hampshire, New York, California, Minnesota and Tennessee.
No illnesses have been reported to date in connection with this problem.
The potential for contamination was noted after a routine sampling of one 5 lb. bag by the Minnesota Department of Agriculture.
Production of the product has been suspended while the company and the FDA continue their investigation as to the source of the problem.
The product comes in 5 lb. green and cream-colored biodegradable film bags with lot number 209-10-27-13 with an expiration date of October 27, 2013.
Consumers who have purchased 5 lb. bags of Steve’s Real Food Turducken Canine Recipe are urged to return them to the place of purchase for a full refund. Consumers with questions should contact the company at 801-540-8481 or firstname.lastname@example.org Monday through Friday from 8:00 am – 5:00 pm MST.
Q&A with Miki Chan of SpaGo Dog
From a corporate office to a mobile dog-grooming van may seem like a demotion, but for Miki Chan, San Francisco Bay Area owner/operator of SpaGo Dog and former insuranceindustry underwriter, it was a huge step up. For 15+ years, Chan devoted her time to the demands of her job. Then one day, her supervisor, who previously had worked for AIG for 25 years and lost most of his net worth when it collapsed, advised her to do what she loved. Taking his advice to heart, she began to plan a way to return to her dog-grooming roots.
Chan had grown up with dogs, and when she was in college earning a degree in computer science with a minor in business, had a part-time job with a groomer, and loved it. So she went back to grooming school, got certified and worked for others to update her skills. Her financial background and marketing insights led her to believe that people would support a grooming salon that came to them. Plus, she didn’t like putting dogs in cages, as happens in most brick-andmortar operations. A mobile set-up would be quiet, personal, relaxing and clean—spa-like, you might say.
Chan finds working with dogs to be joyful, and is gratified that she’s been able to help them by sharing information with their owners on brushing, dental care, and health issues that the grooming process can reveal, such as lumps, skin tags, ear infections and so on.
Besides the sheer pleasure of working with dogs, she’s also glad that she no longer has to deal with office politics, plead for time off or spend endless hours for the benefit of corporate shareholders. We asked if she had any tips for others considering a career change, particularly self-employment, and she shared a few with us. Before jumping, Chan recommends that people be sure they can support their preferred lifestyle (whatever that might be) without their previous paycheck. She also points out that knowing your target audience is crucial, as are time-management and customer-service skills. And being knowledgeable about what you’re doing is key to building trust.
The insurance world’s loss has been the dog world’s gain, and we’d bet the planet’s happiness quotient has gone up a few points as well.
Do you find that people are comfortable with the concept of a mobile groomer?
What’s a typical grooming session like?
When it comes to nail trimming, black nails can be really difficult. What do you advise?
What kinds of things do you see most often?
Wellness: Healthy Living
Lessons learned in the aftermath of Hurricane Sandy
Hurricane sandy claimed hundreds of lives and caused billions of dollars in damage across the Caribbean and along the east coast of the United States. My family was fortunate to have weathered the storm safely, but I learned a lot of things that will help me better prepare my pets for the next storm.
Hunkering Down at Home
Dealing with anxiety. I was fortunate that none of my pets were afraid during the hurricane, but if you know that your dogs are prone to anxiety, it’s good to have a few tools on hand to help them cope, such as a Thundershirt, Dog Appeasing Pheromone (DAP) spray or Rescue Remedy. Just remember to introduce these things before the scary storm so they don’t become part of a bad association.
Potty time. Falling trees killed many people during Hurricane Sandy, including two in New York City who were out walking their dog (the dog was injured but survived). The howling wind was so terrifying that a couple of times, I immediately ran back inside withouteven giving my pups a chance to do their business. I immediately wished I’d prepared an indoor potty area in my garage with a litter box or a tarp filled with dirt and grass. You can also put down housebreaking pads if your dogs will use them.
If you don’t want to bother with a potty area, you should at least determine the safest spots outside. During the storm, I tried to stay as far away as possible from trees and power lines, while watching out for downed wires and other debris.
Surviving blackouts. Power outages were widespread during the hurricane, forcing people to go for days without heat, and some, without running water. Most people I know bundled up and hoped for the best, while others relied on generators (which became tricky because of the gas shortage), or stayed with friends who had heat. The length of the blackouts highlighted the importance of having a backup plan, particularly if you have pets who are sensitive to extreme temperatures. I was lucky to have many friends who offered generators and places to stay, but these are the types of arrangements you want to line up before you need them.
Finding Lost Pets
Preparing to Evacuate
Two things will also make evacuating a lot easier: creating a go bag (see the Pet Evacuation Bag Checklist) and crate-training your dogs. Evacuation centers require pets to be in kennels, and you don’t want an emergency to be the first time your dog sees a crate.
My friends and I endured several days of blackouts, road closures and gas shortages—and we were the lucky ones. Sandy was the second hurricane to hit our area in 14 months and I’m determined to be as prepared as possible for the next one. I know my pets are depending on me.
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